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Serum S-100B protein monitoring in patients with severe traumatic brain injury

Lookup NU author(s): Dr Barbara Gregson, Emeritus Professor David Mendelow


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Objective: S-100B protein is a promising marker of injury severity and outcome after head injury. We examined the relationship between serum S-100B concentrations and injury severity, clinical course, survival, and treatment efficacy after severe traumatic brain injury (TBI). Design and setting: Prospective observational study in a neurosurgical intensive care unit. Patients and participants: 102 adult patients with severe TBI, admitted between June 2001 and November 2003 (30 months). Interventions: Serum S-100B levels were measured by immunoluminometric technique on admission and every 24 h thereafter for a maximum of 7 days. Measurements and results: Initial S-100B levels were significantly related to pupillary status, computed tomography severity1, and 1-month survival. Cox's proportional hazard regression analysis showed that initial S-100B was an independent predictor of 1-month survival, in the presence of dilated pupils, and with increased age. Subjects with initial levels above 1 μg/l had a nearly threefold increased probability of death within 1 month. Serum S-100B alteration indicated neurological improvement or deterioration. Finally, surgical treatment reduced S-100B levels. Conclusions: Serum S-100B protein reflects injury severity and improves prediction of outcome after severe TBI. S-100B may also have a role in assessing the efficacy of treatment after severe TBI. © 2006 Springer-Verlag.

Publication metadata

Author(s): Korfias S, Stranjalis G, Boviatsis E, Psachoulia C, Jullien G, Gregson B, Mendelow AD, Sakas DE

Publication type: Article

Publication status: Published

Journal: Intensive Care Medicine

Year: 2007

Volume: 33

Issue: 2

Pages: 255-260

ISSN (print): 0342-4642

ISSN (electronic): 1432-1238

Publisher: Springer


DOI: 10.1007/s00134-006-0463-4

PubMed id: 17143637


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