ePrints

Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan

Lookup NU author(s): Professor Heather Cordell

Downloads

• Published version [.pdf]

Abstract

Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan using 69 families with 173 affected relatives from two villages occupied by the related Masalit ethnic group. A primary ten-centimorgan scan followed by refined mapping provided evidence for major loci at 1p22 (LOD score 5.65; nominal p=1.72×10-7; empirical p < 1×10-5; λS= 5.1) and 6q27 (LOD score 3.74; nominal p = 1.68 × 10-5; empirical p < 1 × 10-4; λS = 2.3) that were Y chromosome-lineage and village-specific. Neither village supported a visceral leishmaniasis susceptibility gene on 22q12. The results suggest strong lineage-specific genes due to founder effect and consanguinity in these recently immigrant populations. These chance events in ethnically uniform African populations provide a powerful resource in the search for genes and mechanisms that regulate this complex disease. © 2007 Miller et al.

Publication metadata

Author(s): Miller EN, Fadl M, Mohamed HS, Elzein A, Jamieson SE, Cordell HJ, Peacock CS, Fakiola M, Raju M, Khalil EA, Elhassan A, Musa AM, Ibrahim ME, Blackwell JM

Publication type: Article

Publication status: Published

Journal: PLoS Genetics

Year: 2007

Volume: 3

Issue: 5

Pages: 679-688

Print publication date: 01/05/2007

Date deposited: 04/02/2010

ISSN (print): 1553-7390

ISSN (electronic): 1553-7404

Publisher: Public Library of Science

URL: http://dx.doi.org/10.1371/journal.pgen.0030071

DOI: 10.1371/journal.pgen.0030071

Altmetrics

Share