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Efficacy of a new oral lubricant solution in the management of psychotropic drug-induced xerostomia: A randomized controlled trial

Lookup NU author(s): Professor Philip Preshaw


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OBJECTIVE: Xerostomia is a subjective sensation of mouth dryness often occurring as an unwanted effect of psychotropic drugs. METHODS: The clinical efficacy and acceptability of a new oxygenated glycerol triester (OGT) oral spray (1 or 2 sprays up to 4 times daily) in the treatment of xerostomia was compared with those of a commercially available artificial saliva substitute (ASS [Saliveze]) in a 2-week, open-labeled, randomized, parallel-group study. Clinical assessment of xerostomia included evaluation of mouth dryness by means of a 10-cm-long visual analog scale, objective blinded assessment of the oral tissue condition by a dental hygienist by means of a 4-point ordinal scale, and subjective patient-based assessment of dry mouth symptoms by means of dichotomous responses to a questionnaire. [Day 14 - baseline] patient-based mouth dryness score was the primary end point. RESULTS: Seventy-four patients (41 women and 33 men, 44 ± 15 years) undergoing long-term psychotropic drug treatment were consecutively enrolled. At day 14, OGT resulted in better efficacy than ASS in mouth dryness score (mean difference, 1.2 ± 0.4; P = 0.006), speech difficulties (mean difference, 1.2 ± 0.4; P = 0.005), taste (mean difference, 1.1 ± 0.4; P = 0.02), and overall mouth condition (mean difference, 1.4 ± 0.9; P = 0.005). Taste of OGT was better than that of ASS (mean difference, 1.4 ± 0.6; P = 0.04), as was OGT acceptability (mean difference, 1.4 ± 0.9; P = 0.005). CONCLUSION: Oxygenated glycerol triester lubricant oral spray was superior to a commercially available ASS in improving xerostomia and overall condition of the oral tissue. © 2007 Lippincott Williams & Wilkins, Inc.

Publication metadata

Author(s): Mouly SJ, Orler J-B, Tillet Y, Coudert A-C, Oberli F, Preshaw P, Bergmann J-F

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Psychopharmacology

Year: 2007

Volume: 27

Issue: 5

Pages: 437-443

Print publication date: 01/10/2007

ISSN (print): 0271-0749

ISSN (electronic): 1533-712X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/jcp.0b013e31814db434

PubMed id: 17873673


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