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Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska
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We have used a systemic approach to establish a relationship between enzyme measures of glial glutamate and energy metabolism (glutamine synthetase and glutamine synthetase-like protein, glutamate dehydrogenase isoenzymes, brain isoform creatine phosphokinase) and two major glial proteins (glial fibrillary acidic protein and myelin basic protein) in autopsied brain samples taken from patients with schizophrenia (SCH) and mentally healthy subjects (23 and 22 cases, respectively). These biochemical parameters were measured in tissue extracts in three brain areas (prefrontal cortex, caudate nucleus, and cerebellum). Significant differences in the level of at least one of the glutamate metabolizing enzymes were observed between two studied groups in all studied brain areas. Different patterns of correlative links between the biochemical parameters were found in healthy and schizophrenic brains. These findings give a new perspective to our understanding of the impaired regulation of enzyme levels in the brain in SCH. © 2007 Springer Science+Business Media, LLC.
Author(s): Burbaeva GSh, Boksha IS, Tereshkina EB, Savushkina OK, Starodubtseva LI, Turishcheva MS, Mukaetova-Ladinska E
Publication type: Article
Publication status: Published
Journal: Neurochemical Research
Year: 2007
Volume: 32
Issue: 9
Pages: 1434-1444
ISSN (print): 0364-3190
ISSN (electronic): 1573-6903
Publisher: Springer New York LLC
URL: http://dx.doi.org/10.1007/s11064-007-9328-7
DOI: 10.1007/s11064-007-9328-7
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