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Platelet activation in bypass surgery for critical limb ischemia

Lookup NU author(s): Professor Gerard Stansby


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Platelet activation contributes to graft occlusion after bypass surgery. This study investigated platelet activation status before, during, and after bypass. Blood was taken preoperatively from patients undergoing femoro-popliteal bypass and at incision, after dissection, after ischemia, after reperfusion, 24 hours after surgery, and almost 2 years after bypass (and given aspirin or warfarin). Platelet aggregation was measured using a turbidimetric method and platelet activation with flow cytometry. Statistical analysis was performed using Mann-Whitney U and Wilcoxon's tests. Resting platelet activation was similar between controls and patients undergoing bypass. Platelet activation decreased at incision but remained highly reactive. Platelet aggregation increased after dissection and the ischemic phase but significantly decreased after reperfusion. Platelet aggregation and activation were increased at 24 hours and subsequently after bypass. Platelets in critical limb ischemia exist in the primed state and become activated by minimum stimuli. Increased platelet activation occurs after bypass grafting for critical limb ischemia despite adjunctive therapy. © 2007 Sage Publications.

Publication metadata

Author(s): Mohan IV, Mikhailidis DP, Stansby GP

Publication type: Article

Publication status: Published

Journal: Vascular and Endovascular Surgery

Year: 2007

Volume: 41

Issue: 4

Pages: 322-329

ISSN (print): 1538-5744

ISSN (electronic): 1938-9116

Publisher: Sage Publications, Inc.


DOI: 10.1177/1538574407302753

PubMed id: 17704335


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