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Lookup NU author(s): Professor Ruth Plummer,
Professor Alan Calvert
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The DNA repair pathways are protective of the host genome in normal cells; however, in cancer cells, these pathways may be disrupted and predispose to tumorigenesis or their activity may overcome the potentially cytotoxic damage caused by anticancer agents and be a mechanism of resistance. Poly(ADP-ribose) polymerase inhibitors, which block base excision repair of single-strand breaks, have entered the clinic in the last few years. This article discusses the interactions between the pathways of single- and double-strand break repair, which explain the two clinical development strategies for this class of drugs. ©2007 American Association for Cancer Research.
Author(s): Plummer ER, Calvert AH
Publication type: Article
Publication status: Published
Journal: Clinical Cancer Research
Print publication date: 01/11/2007
ISSN (print): 1078-0432
ISSN (electronic): 1557-3265
PubMed id: 17975135
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