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The role of intracellular peroxide levels on the development and maintenance of telomere-dependent senescence

Lookup NU author(s): Torsten Richter, Dr Carole Proctor

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Abstract

The fact that reactive oxygen species (ROS) influences telomere-shortening and with it the onset of senescence in cells is well known, but a detailed model describing this correlation has not been proposed so far. Based on experimental data, that span a wide range of intracellular peroxide levels we formulate here a deterministic equation and a stochastic model that describe this connection, taking into account biological functions such as DNA damage and repair. Through simulations of population development under oxidative stress and dynamics of telomere length distributions, we show that a subset of uncapped telomeres is required for cell cycle arrest. Our model also supports a possible mechanism by which the generation of ROS as a consequence of telomere dysfunction leads to a positive feedback that accelerates telomere erosion. In this model, telomere-state and ROS would mutually influence each other. © 2007 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Richter T, Proctor CJ

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2007

Volume: 42

Issue: 11

Pages: 1043-1052

Print publication date: 01/11/2007

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier Inc.

URL: http://dx.doi.org/10.1016/j.exger.2007.08.004

DOI: 10.1016/j.exger.2007.08.004

PubMed id: 17888604

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