ePrints

Asymmetric hydrogenation of ketones with ruthenium complexes of rac- and enantiopure (S,S)-1,2-bis((diphenylphosphino)methyl)cyclohexane: A comparative study with rac- and (R)-BINAP

Lookup NU author(s): Dr Simon DohertyORCiD, Dr Julian Knight, Adam Bell, Dr Ross Harrington, Professor William Clegg

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Ruthenium(II) complexes of the type trans-[RuCl2-{1,2- bis((diphenylphosphino)methyl)cyclohexane}(diamine)]based on the inexpensive and easy-to-prepare rac- and (S,S)-1,2-bis-((diphenylphosphino)methyl) cyclohexaneform highly active and enantioselective catalysts for the asymmetric hydrogenation of a wide range of aryl and heteroaryl ketones, in most cases giving ee's that exceed those obtained with their BINAP counterparts. Although precatalysts based on 1,2-bis((diphenylphosphino)-methyl)cyclohexane slowly isomerize in solution to afford the thermodynamically favored isomer with a cis arrangement of chlorides, catalysts generated from both isomers afford similar enantioselectivities. © 2007 American Chemical Society.

Publication metadata

Author(s): Doherty S, Knight JG, Bell AL, Harrington RW, Clegg W

Publication type: Article

Publication status: Published

Journal: Organometallics

Year: 2007

Volume: 26

Issue: 9

Pages: 2465-2468

ISSN (print): 0276-7333

ISSN (electronic): 1520-6041

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/om070129i

DOI: 10.1021/om070129i

Altmetrics

Share