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Metabolic disease and cardiovascular risk in people treated with antipsychotics in the community

Lookup NU author(s): Dr Paul Mackin, Helen Watkinson, Dr Peter Gallagher, Emeritus Professor Nicol Ferrier

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Abstract

Background: Prevalence of physical comorbidity in severe mental illness is a significant public health concern, but comparative data in people with diagnoses other than schizophrenia are sparse. Aims: To investigate the prevalence of metabolic disease and cardiovascular risk in people with severe mental illness treated with antipsychotics in the community. Methods: Case-control study of 90 people treated with antipsychotics in the community and 92 age- and gender-matched controls. The prevalence of metabolic syndrome and 10-year cardiovascular risk were calculated. Results: People on antipsychotics had a significantly worse metabolic profile than controls (F=6.583, d.f.=15,161, P < 0.0001). Moreover, metabolic syndrome was more prevalent (OR=3.68, 95% CI 1.71-7.93, P=0.001), as was cardiovascular risk across a number of outcomes. These results are consistent across diagnostic groups. Conclusions: People with severe mental illness treated with antipsychotics have excess metabolic dysfunction and heightened risk for cardiovascular disease.


Publication metadata

Author(s): Mackin P, Bishop D, Watkinson H, Gallagher P, Ferrier IN

Publication type: Article

Publication status: Published

Journal: British Journal of Psychiatry

Year: 2007

Volume: 191

Pages: 23-29

Print publication date: 01/07/2007

ISSN (print): 0007-1250

ISSN (electronic): 1472-1465

Publisher: Royal College of Psychiatrists

URL: http://dx.doi.org/10.1192/bjp.bp.106.031716

DOI: 10.1192/bjp.bp.106.031716

PubMed id: 17602121


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