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Lookup NU author(s): Dr Paul Mackin,
Dr Peter GallagherORCiD,
Emeritus Professor Nicol Ferrier
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Background: Prevalence of physical comorbidity in severe mental illness is a significant public health concern, but comparative data in people with diagnoses other than schizophrenia are sparse. Aims: To investigate the prevalence of metabolic disease and cardiovascular risk in people with severe mental illness treated with antipsychotics in the community. Methods: Case-control study of 90 people treated with antipsychotics in the community and 92 age- and gender-matched controls. The prevalence of metabolic syndrome and 10-year cardiovascular risk were calculated. Results: People on antipsychotics had a significantly worse metabolic profile than controls (F=6.583, d.f.=15,161, P < 0.0001). Moreover, metabolic syndrome was more prevalent (OR=3.68, 95% CI 1.71-7.93, P=0.001), as was cardiovascular risk across a number of outcomes. These results are consistent across diagnostic groups. Conclusions: People with severe mental illness treated with antipsychotics have excess metabolic dysfunction and heightened risk for cardiovascular disease.
Author(s): Mackin P, Bishop D, Watkinson H, Gallagher P, Ferrier IN
Publication type: Article
Publication status: Published
Journal: British Journal of Psychiatry
Print publication date: 01/07/2007
ISSN (print): 0007-1250
ISSN (electronic): 1472-1465
Publisher: Royal College of Psychiatrists
PubMed id: 17602121
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