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Diaryliodonium salts: A solution to 3-(18F)fluoropyridine

Lookup NU author(s): Dr Michael Carroll, John Woodcraft


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Fluorine-18 labelled fluoropyridines have found increasing application in the medical imaging technique of Positron Emission Tomography. The fluorine-18 has largely been restricted to the 2- and 6-position where its introduction may be readily achieved, from a range of appropriate precursors, by nucleophilic aromatic substitution using [18F]fluoride. However, fluorine at this position may be labile in vivo limiting the potential of the radiotracer. To date the more stable 3-fluoro and 5-fluoropyridines have not been exploited due to unsuitable methods of preparation. Pyridyliodonium salts provide a convenient way to overcome this restriction and allow the introduction of fluorine-18, as fluoride, into the 3- or 5-position. Copyright © 2007 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Carroll MA, Nairne J, Woodcraft JL

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Journal of Labelled Compounds and Radiopharmaceuticals: Proceedings of the Ninth International Symposium on the Synthesis and Applications of Isotopically Labelled Compounds

Year of Conference: 2007

Pages: 452-454

ISSN: 0362-4803

Publisher: Wiley-Blackwell


DOI: 10.1002/jlcr.1190

Library holdings: Search Newcastle University Library for this item

ISBN: 10991344