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Plasmid segregation: Spatial awareness at the molecular level

Lookup NU author(s): Professor Kenn Gerdes



In bacteria, low-copy number plasmids ensure their stable inheritance by partition loci (par), which actively distribute plasmid replicates to each side of the cell division plane. Using time-lapse fluorescence microscopic tracking of segregating plasmid molecules, a new study provides novel insight into the workings of the par system from Escherichia coli plasmid R1. Despite its relative simplicity, the plasmid partition spindle shares characteristics with the mitotic machinery of eukaryotic cells. © The Rockefeller University Press.

Publication metadata

Author(s): Moller-Jensen J, Gerdes K

Publication type: Review

Publication status: Published

Journal: Journal of Cell Biology

Year: 2007

Volume: 179

Issue: 5

Pages: 813-815

Print publication date: 03/12/2007

ISSN (print): 0021-9525

ISSN (electronic): 1540-8140


DOI: 10.1083/jcb.200710192

PubMed id: 18039938