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Experimental Strategies Towards Treating Mitochondrial DNA Disorders

Lookup NU author(s): Dr Julie Murphy, Dr Lyndsey Butterworth, Emeritus Professor Doug Turnbull, Professor Robert Taylor

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Abstract

An extensive range of molecular defects have been identified in the human mitochondrial genome (mtDNA), causing a range of clinical phenotypes characterized by mitochondrial respiratory chain dysfunction. Sadly, given the complexities of mitochondrial genetics, there are no available cures for mtDNA disorders. In this review, we consider experimental, genetic-based strategies that have been or are being explored towards developing treatments, focussing on two specific areas which we are actively pursuing-assessing the benefit of exercise training for patients with mtDNA defects, and the prevention of mtDNA disease transmission. © 2007 The Biochemical Society.

Publication metadata

Author(s): Gardner JL, Craven L, Turnbull DM, Taylor RW

Publication type: Article

Publication status: Published

Journal: Bioscience Reports

Year: 2007

Volume: 27

Issue: 1-3

Pages: 139-150

ISSN (print): 0144-8463

ISSN (electronic): 1573-4935

Publisher: The Biochemical Society

URL: http://dx.doi.org/10.1007/s10540-007-9042-3

DOI: 10.1007/s10540-007-9042-3

PubMed id: 17492502

Notes: Co-author JL Gardner now publishes as JL Murphy.

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