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Lookup NU author(s): Dr Julie Murphy,
Dr Lyndsey Butterworth,
Emeritus Professor Doug Turnbull,
Professor Robert Taylor
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
An extensive range of molecular defects have been identified in the human mitochondrial genome (mtDNA), causing a range of clinical phenotypes characterized by mitochondrial respiratory chain dysfunction. Sadly, given the complexities of mitochondrial genetics, there are no available cures for mtDNA disorders. In this review, we consider experimental, genetic-based strategies that have been or are being explored towards developing treatments, focussing on two specific areas which we are actively pursuing-assessing the benefit of exercise training for patients with mtDNA defects, and the prevention of mtDNA disease transmission. © 2007 The Biochemical Society.
Author(s): Gardner JL, Craven L, Turnbull DM, Taylor RW
Publication type: Article
Publication status: Published
Journal: Bioscience Reports
ISSN (print): 0144-8463
ISSN (electronic): 1573-4935
Publisher: The Biochemical Society
PubMed id: 17492502
Notes: Co-author JL Gardner now publishes as JL Murphy.
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