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Biologic therapies in rheumatology: Lessons learned, future directions

Lookup NU author(s): Professor John IsaacsORCiD


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During the past decade biologic therapies such as monoclonal antibodies and fusion proteins have revolutionized the management of rheumatic disease. By targeting key cytokines and immune cells biologics have provided more specific therapeutic interventions with less immunosuppression. Clinical use, however, has revealed that their theoretical simplicity hides a more complex reality. Efficacy, toxicity and even pharmacodynamic effects can deviate from those predicted, as poignantly illustrated by the catastrophic effects witnessed during the first-into-human administration of TGN1412. This review summarizes lessons gleaned from practical experience and discusses how these can inform future discovery and development of new biologic therapies for rheumatology.

Publication metadata

Author(s): Strand V, Kimberly R, Isaacs JD

Publication type: Review

Publication status: Published

Journal: Nature Reviews Drug Discovery

Year: 2007

Volume: 6

Issue: 1

Pages: 75-92

Print publication date: 01/01/2007

ISSN (print): 1474-1776

ISSN (electronic): 1474-1784


DOI: 10.1038/nrd2196

PubMed id: 17195034