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MRI for the demonstration of subclinical muscle involvement in muscular dystrophy

Lookup NU author(s): Dr Iain McKinnonORCiD, Emerita Professor Katherine Bushby, Professor Patrick Chinnery, Dr Daniel Birchall



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Aim: To compare magnetic resonance imaging (MRI) with clinical examination for the detection of muscle abnormality in patients with muscular dystrophy. Methods: Muscle power in 20 patients with a variety of forms of muscular dystrophy was examined clinically using the Medical Research Council (MRC) grading scale, and patients were subsequently imaged with MRI. MRI and clinical examination for the detection of muscle normality and abnormality were compared using a McNemar chi-squared test to examine differences between the two methods. Results: MRI demonstrated radiological evidence of muscle abnormality more often than clinical examination; 50% of movements assessed as normal on clinical examination were associated with muscle abnormalities on MRI, including a significant proportion where there was severe radiological abnormality, indicating that focally advanced disease may be undetectable clinically. Conclusion: The combination of clinical examination and MRI could improve the accuracy of phenotypic characterization of patients with muscular dystrophy, and this in turn could allow a more focussed molecular analysis through muscle biopsy or genetic investigation. This may also be very helpful in the assessment of the degree of muscle compromise not only in the early phases of the disease but especially during follow-up and can be used in therapeutic trials. © 2006 The Royal College of Radiologists.

Publication metadata

Author(s): Sookhoo S, McKinnon I, Bushby K, Chinnery PF, Birchall D

Publication type: Article

Publication status: Published

Journal: Clinical Radiology

Year: 2007

Volume: 62

Issue: 2

Pages: 160-165

Print publication date: 01/02/2007

Online publication date: 03/01/2007

Date deposited: 23/01/2018

ISSN (print): 0009-9260

ISSN (electronic): 1365-229X

Publisher: WB Saunders Co. Ltd.


DOI: 10.1016/j.crad.2006.08.012

PubMed id: 17207699


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