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Deterioration in quality of life and depressive symptoms during radiation therapy for head and neck cancer

Lookup NU author(s): Dr Charles Kelly, Professor Vinidh Paleri


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Objective: The aim of this study was to assess the quality of life and psychologic profile during radiation therapy for head and neck cancer. Study design and setting: The University of Washington QoL instrument and the Hospital Anxiety and Depression Scale were administered to 202 patients at two or three time points during radiation therapy. Results: A total of 118 (54.6%) patients completed the questionnaires at the beginning and at the end of the study. A mid-treatment dataset was also available for 67 (31.0%) patients. There was a statistically significant deterioration in composite QoL scores (P < 0.000) and a statistically significant increase in depression (P < 0.000). There was no difference in anxiety levels (P = 0.276). Conclusion: Patients undergoing radiation are increasingly depressed as treatment progresses, with worsening QoL during the treatment. Significance: This study underlines the need for good psychologic support during radiation therapy in head and neck cancer. © 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation.

Publication metadata

Author(s): Kelly C, Paleri V, Downs C, Shah R

Publication type: Article

Publication status: Published

Journal: Otolaryngology - Head and Neck Surgery

Year: 2007

Volume: 136

Issue: 1

Pages: 108-111

Print publication date: 01/01/2007

ISSN (print): 0194-5998

ISSN (electronic): 1097-6817

Publisher: Mosby, Inc.


DOI: 10.1016/j.otohns.2006.06.1278

PubMed id: 17210344


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