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Lookup NU author(s): Professor Andrew Jackson
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We describe a small, chronically implantable microwire array for obtaining long-term unit recordings from the cortex of unrestrained nonhuman primates. After implantation, the depth of microwires can be individually adjusted to maintain large-amplitude action potential recordings from single neurons over many months. We present data recorded from the primary motor cortex of two monkeys by autonomous on-board electronic circuitry. Waveforms of individual neurons remained stable for recording periods of several weeks during unrestrained behavior. Signal-to-noise ratios, waveform stability, and rates of cell loss indicate that this method may be particularly suited to experiments investigating the neural correlates of processes extending over multiple days, such as learning and plasticity. Copyright © 2007 The American Physiological Society.
Author(s): Jackson A, Fetz EE
Publication type: Article
Publication status: Published
Journal: Journal of Neurophysiology
Year: 2007
Volume: 98
Issue: 5
Pages: 3109-3118
ISSN (print): 0022-3077
ISSN (electronic): 1522-1598
Publisher: American Physiological Society
URL: http://dx.doi.org/10.1152/jn.00569.2007
DOI: 10.1152/jn.00569.2007
PubMed id: 17855584
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