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Lookup NU author(s): Professor Julia NewtonORCiD
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The autoimmune liver disease, primary biliary cirrhosis (PBC), is associated with debilitating fatigue in a significant proportion of patients. The pathogenesis of fatigue in PBC is unclear, but preliminary studies suggest it has central mechanisms and may have peripheral manifestations. Studies are beginning to elucidate the biological associates of fatigue in PBC, particularly sleep disturbance and autonomic dysfunction. Comprehensive studies investigating the pathogenesis of fatigue in PBC are urgently needed as are large-scale prospective outcome studies. © 2008 Elsevier Inc. All rights reserved.
Author(s): Newton JL
Publication type: Review
Publication status: Published
Journal: Clinics in Liver Disease
Print publication date: 01/05/2008
ISSN (print): 1089-3261
ISSN (electronic): 1557-8224
PubMed id: 18456186