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Fatigue in Primary Biliary Cirrhosis

Lookup NU author(s): Emerita Professor Julia Newton


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The autoimmune liver disease, primary biliary cirrhosis (PBC), is associated with debilitating fatigue in a significant proportion of patients. The pathogenesis of fatigue in PBC is unclear, but preliminary studies suggest it has central mechanisms and may have peripheral manifestations. Studies are beginning to elucidate the biological associates of fatigue in PBC, particularly sleep disturbance and autonomic dysfunction. Comprehensive studies investigating the pathogenesis of fatigue in PBC are urgently needed as are large-scale prospective outcome studies. © 2008 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Newton JL

Publication type: Review

Publication status: Published

Journal: Clinics in Liver Disease

Year: 2008

Volume: 12

Issue: 2

Pages: 367-383

Print publication date: 01/05/2008

ISSN (print): 1089-3261

ISSN (electronic): 1557-8224


DOI: 10.1016/j.cld.2008.02.010

PubMed id: 18456186