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Lookup NU author(s): Dr Arun Natarajan,
Professor Azfar Zaman,
Emerita Professor Sally Marshall
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Type 2 diabetes mellitus increases atherothrombotic risk. Platelets in individuals with diabetes show increased activity at baseline and in response to agonists, ultimately leading to increased aggregation. Increased expression of platelet surface adhesion molecules and receptors, enhanced production of thromboxane and thrombin and disturbances in platelet calcium homeostasis are well documented. As intra-arterial thrombi are initiated by platelets, strategies to limit acute thrombotic events have largely focused on antiplatelet agents. Aspirin remains the cornerstone of antiplatelet therapy but appears to have limited benefit in diabetes. Use of thienopyridines and platelet glycoprotein IIb/IIa receptor inhibitors has been shown to benefit high-risk patient populations. This review summarises the different platelet abnormalities characterised in diabetes and the role of currently used antiplatelet agents.
Author(s): Natarajan A, Zaman AG, Marshall SM
Publication type: Article
Publication status: Published
Journal: Diabetes and Vascular Disease Research
ISSN (print): 1479-1641
ISSN (electronic): 1752-8984
Publisher: Sage Publications Ltd.
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