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Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7

Lookup NU author(s): Professor Roderick Skinner, Dr Mark Velangi, Dr Nicholas Bown

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Abstract

An 8-year-old male relapsed with refractory anemia with excess blasts (RAEB) and monosomy 7 and mixed chimerism (MC) 21 months after HLA-matched unrelated donor bone marrow transplant (BMT). He received three donor lymphocyte infusions (DLI) using an escalating dose schedule. He developed grade II acute graft-versus-host disease (GVHD) 9 days after the third DLI, but continued to deteriorate for 2 months with decreasing marrow cellularity but persisting blasts, MC, and monosomy 7, before exhibiting a delayed but complete response which has persisted for 5 years. This case suggests that DLI and graft-versus-myelodysplasia (GVMDS) may be beneficial in post-transplant relapse of pediatric myelodysplasia. © 2007 Wiley-Liss, Inc.

Publication metadata

Author(s): Skinner R, Velangi M, Bown NP

Publication type: Article

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2008

Volume: 50

Issue: 3

Pages: 670-672

ISSN (print): 1545-5009

ISSN (electronic): 1096-911X

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.21146

DOI: 10.1002/pbc.21146

PubMed id: 17253642

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