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LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium

Lookup NU author(s): Dr Michail Karavolos, Dr David Bulmer, Dr Anjam Khan


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LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Publication metadata

Author(s): Karavolos MH, Bulmer DM, Winzer K, Wilson M, Mastroeni P, Williams P, Khan CMA

Publication type: Article

Publication status: Published

Journal: Journal of Bacteriology

Year: 2008

Volume: 190

Issue: 2

Pages: 769-771

ISSN (print): 0021-9193

ISSN (electronic): 1098-5530

Publisher: American Society for Microbiology


DOI: 10.1128/JB.01253-07

PubMed id: 18024511


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Funder referenceFunder name
D17313Biotechnology and Biological Sciences Research Council
G0501449Medical Research Council