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Polymorphisms of cytokine and innate immunity genes and GVHD

Lookup NU author(s): Professor Anne Dickinson

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Abstract

In the last 10 years, non-HLA genotypes have been investigated for their potential roles in the occurrence and severity of graft-versus-host disease (GVHD) as well as for their contribution to overall transplant-related mortality, infectious episodes, and overall survival. This chapter will review the latest results of cytokine gene polymorphisms between patient and donor which may cause the production of high or low levels of cytokines during the three-stage process of the GVHD 'cytokine storm'. More recent investigations into innate immunity and the interaction with subsequent downstream cytokine production and ultimate tissue damage are discussed. The potential of these non-HLA genetics to aid in predicting GVHD and post-transplant survival and the relevance of this information to the clinic are reviewed. © 2008 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Dickinson AM, Holler E

Publication type: Article

Publication status: Published

Journal: Best Practice & Research: Clinical Haematology

Year: 2008

Volume: 21

Issue: 2

Pages: 149-164

ISSN (print): 1521-6926

ISSN (electronic): 1532-1924

Publisher: Bailliere Tindall

URL: http://dx.doi.org/10.1016/j.beha.2008.03.004

DOI: 10.1016/j.beha.2008.03.004

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