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Metalloproteases as potential therapeutic targets in arthritis treatment

Lookup NU author(s): Emeritus Professor Drew Rowan, Dr Gary Litherland, Dr Jenny Milner


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Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for therapeutic intervention for some time, although clinical efficacy has been elusive. Members of the 'A disintegrin and metalloprotease with thrombospondin motifs' and matrix metalloprotease families are considered to be collectively responsible for cartilage catabolism, such that inhibition of these activities is theoretically a highly attractive strategy for preventing further proteolytic damage. This review outlines the biology of these metalloproteases and what we have learnt from inhibition studies and transgenics, and highlights the important questions that this information raises for the future development of therapeutics directed towards metalloproteases for arthritis treatment. © 2008 Informa UK Ltd.

Publication metadata

Author(s): Rowan AD, Litherland GJ, Hui W, Milner JM

Publication type: Review

Publication status: Published

Journal: Expert Opinion on Therapeutic Targets

Year: 2008

Volume: 12

Issue: 1

Pages: 1-18

ISSN (print): 1472-8222

ISSN (electronic): 1744-7631


DOI: 10.1517/14728222.12.1.1

PubMed id: 18076366