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Lookup NU author(s): Emeritus Professor Drew Rowan, Dr Gary Litherland, Dr Jenny Milner
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Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for therapeutic intervention for some time, although clinical efficacy has been elusive. Members of the 'A disintegrin and metalloprotease with thrombospondin motifs' and matrix metalloprotease families are considered to be collectively responsible for cartilage catabolism, such that inhibition of these activities is theoretically a highly attractive strategy for preventing further proteolytic damage. This review outlines the biology of these metalloproteases and what we have learnt from inhibition studies and transgenics, and highlights the important questions that this information raises for the future development of therapeutics directed towards metalloproteases for arthritis treatment. © 2008 Informa UK Ltd.
Author(s): Rowan AD, Litherland GJ, Hui W, Milner JM
Publication type: Review
Publication status: Published
Journal: Expert Opinion on Therapeutic Targets
Year: 2008
Volume: 12
Issue: 1
Pages: 1-18
ISSN (print): 1472-8222
ISSN (electronic): 1744-7631
URL: http://dx.doi.org/10.1517/14728222.12.1.1
DOI: 10.1517/14728222.12.1.1
PubMed id: 18076366
