Browse by author
Lookup NU author(s): Dr Tuomo Polvikoski
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background. Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA. Methods. Here we have studied the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population-based Vantaa 85+ Autopsy Study (n = 256). The diagnosis of SSA was based on histological examination of myocardial samples stained with Congo red and anti-TTR immunohistochemistry. The genotype frequencies of 20 polymorphisms in 9 genes in subjects with and without SSA were compared. Results. The prevalence of SSA was 25%. SSA was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (α2M), and the H2 haplotype of the tau gene (P-values 0.002, 0.004, 0.042, and 0.016). Conclusion. This population-based study shows that SSA is very common in old individuals, affecting one-quarter of people aged over 85 years. Myocardial infarctions and variation in the genes for α2M and tau may be associated with SSA. © 2008 Informa UK Ltd.
Author(s): Tanskanen M, Peuralinna T, Polvikoski T, Notkola I-L, Sulkava R, Hardy J, Singleton A, Kiuru-Enari S, Paetau A, Tienari PJ, Myllykangas L
Publication type: Article
Publication status: Published
Journal: Annals of Medicine
ISSN (print): 0785-3890
ISSN (electronic): 1365-2060
Publisher: Taylor & Francis A B
PubMed id: 18382889
Altmetrics provided by Altmetric