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Antifouling activity of meroditerpenoids from the marine brown alga halidrys siliquosa

Lookup NU author(s): Dr Claire Hellio, Professor Tony Clare


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Nine tetraprenyltoluquinol-related metabolites (1-9) have been isolated from the organic extract of the temperate brown alga Halidrys siliquosa that exhibits antifouling properties. The planar structure of compounds 1-9 was elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Antifouling and toxicity tests were conducted on these compounds: the most active (compounds 2, 6, and 9) inhibited both the growth of four strains of bacteria (MICs < 2.5 μg/mL) and settlement of cyprids of Balanus amphitrite (EC50 < 5 μg/mL), the latter at nontoxic concentrations (LC50 > 5 μg/mL). © 2008 American Chemical Society and American Society of Pharmacognosy.

Publication metadata

Author(s): Gerald Culioli A, Valls R, Hellio C, Clare AS, Piovetti L

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2008

Volume: 71

Issue: 7

Pages: 1121-1126

Print publication date: 01/07/2008

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society


DOI: 10.1021/np070110k


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