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A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

Lookup NU author(s): Dr Lynsey Cree, Professor Patrick Chinnery

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Abstract

Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but the mechanisms involved are not fully understood. Females harboring a mixture of mutant and wild-type mtDNA (heteroplasmy) transmit a varying proportion of mutant mtDNA to their offspring. In humans with mtDNA disorders, the proportion of mutated mtDNA inherited from the mother correlates with disease severity. Rapid changes in allele frequency can occur in a single generation. This could be due to a marked reduction in the number of mtDNA molecules being transmitted from mother to offspring (the mitochondrial genetic bottleneck), to the partitioning of mtDNA into homoplasmic segregating units, or to the selection of a group of mtDNA molecules to re-populate the next generation. Here we show that the partitioning of mtDNA molecules into different cells before and after implantation, followed by the segregation of replicating mtDNA between proliferating primordial germ cells, is responsible for the different levels of heteroplasmy seen in the offspring of heteroplasmic female mice. © 2008 Nature Publishing Group.


Publication metadata

Author(s): Cree L, Samuels D, De Sousa Lopes S, Rajasimha H, Wonnapinij P, Mann J, Dahl H, Chinnery P

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2008

Volume: 40

Issue: 2

Pages: 249-254

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ng.2007.63

DOI: 10.1038/ng.2007.63

PubMed id: 18223651


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