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Clinical Immunology Review Series: An approach to the patient with recurrent infections in childhood

Lookup NU author(s): Professor Mary Slatter, Professor Andrew GenneryORCiD


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Recurrent or persistent infection is the major manifestation of primary immunodeficiency, which also results in atypical infection with opportunistic organisms. Young children are also vulnerable to infection and recurrent infection is common. While most children with recurrent infection have a normal immunity, it is important to recognize the child with an underlying primary immunodeficiency and investigate and treat appropriately and yet not over investigate normal children. Prompt, accurate diagnosis directs the most appropriate treatment, and early and judicious use of prophylactic antibiotics and replacement immunoglobulin can prevent significant end organ damage and improve long-term outlook and quality of life. This paper describes important presenting features of primary immunodeficiency and indicates when further investigation is warranted. © 2008 British Society for Immunology.

Publication metadata

Author(s): Slatter MA, Gennery AR

Publication type: Review

Publication status: Published

Journal: Clinical and Experimental Immunology

Year: 2008

Volume: 152

Issue: 3

Pages: 389-396

ISSN (print): 0009-9104

ISSN (electronic): 1365-2249


DOI: 10.1111/j.1365-2249.2008.03641.x

PubMed id: 18373701