Toggle Main Menu Toggle Search

Open Access padlockePrints

The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation

Lookup NU author(s): Professor Anne Dickinson, Professor Graham Jackson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Previous studies from our group indicated a role of SNPs within the innate immunity receptor NOD2/CARD15 as a risk factor for GvHD and treatment-related mortality allogeneic stem cell transplantation from HLA-identical siblings. We now extended these studies to assess the role of NOD2/CARD15 SNPs in 342 unrelated donor transplants. Overall, presence of any SNPs in patients or donor resulted in an increased risk of severe GvHD (25% in wildtype versus 38% in recipients and donors with variants, P = 0.01), which did not translate in increased mortality. When the analysis was broken down to individual SNPs, the presence of a SNP13 in the donor turned out to be the only highly significant risk factor (GvHD III/IV 22% wt, 42% SNP13 donor, P < 0.004; TRM 33% wt versus 59% SNP13 donor, P = 0.01; overall survival 49% wt versus 26% SNP13 donor, P = 0.007). This association was confirmed in multivariate analysis. Analysis of clinical risk factors suggested that this effect was most prominent in patients receiving any form of T cell depletion. Thus our observation indicates that the presence of a defect in innate immunity signalling in donor monocytes and possibly antigen presenting cells is most prominent in patients having additional T cell deficiency. © 2008 The Authors.

Publication metadata

Author(s): Holler E, Rogler G, Brenmoehl J, Hahn J, Greinix H, Dickinson AM, Socie G, Wolff D, Finke J, Fischer G, Jackson G, Rocha V, Hilgendorf I, Eissner G, Marienhagen J, Andreesen R

Publication type: Article

Publication status: Published

Journal: International Journal of Immunogenetics

Year: 2008

Volume: 35

Issue: 4-5

Pages: 381-384

ISSN (print): 1744-3121

ISSN (electronic): 1744-313X

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1744-313X.2008.00795.x


Altmetrics provided by Altmetric


Funder referenceFunder name
MRTN-CT-2004512253the European Commission
QLRT-2000-00010the European Commission
QLRT-CT-2001-01936the European Commission