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Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury

Lookup NU author(s): Dr Stephen Stewart

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Abstract

Inflammation is recognized increasingly as having an important role in the pathogenesis of alcoholic liver disease (ALD). Nonetheless, the mechanisms by which alcohol maintains hepatic inflammation are still characterized incompletely. Several studies have demonstrated that ethanol-induced oxidative stress promotes immune responses in ALD by stimulating both humoral and cellular reactions against liver proteins adducted to hydroxyethyl free radicals and several lipid peroxidation products. Moreover, ALD patients have autoantibodies targeting cytochrome P4502E1 and oxidized phospholipids. In both chronic alcohol-fed rats and heavy drinkers, the elevation of IgG against lipid peroxidation-derived antigens is associated with tumor necrosis factor-α production and the severity of liver inflammation. On this basis, we propose that allo- and autoimmune reactions associated with oxidative stress might contribute to fueling hepatic inflammation in ALD. © 2007 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Vidali M, Stewart SF, Albano E

Publication type: Article

Publication status: Published

Journal: Trends in Molecular Medicine

Year: 2008

Volume: 14

Issue: 2

Pages: 63-71

ISSN (print): 1471-4914

ISSN (electronic): 1471-499X

Publisher: Elsevier Ltd., Trends Journals

URL: http://dx.doi.org/10.1016/j.molmed.2007.12.005

DOI: 10.1016/j.molmed.2007.12.005

PubMed id: 18222109

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