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An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation

Lookup NU author(s): Professor Anne Dickinson


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In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94+ NK cells. In the first 12 months after stem cell transplantation (SCT) CD94+ NK cells clearly dominate over CD3+/CD16-/56- T and CD3+/CD16+/56+ NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells. © 2007 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Gross C, Holler E, Stangl S, Dickinson AM, Pockley AG, Asea AA, Mallappa N, Multhoff G

Publication type: Article

Publication status: Published

Journal: Leukemia Research

Year: 2008

Volume: 32

Issue: 4

Pages: 527-534

ISSN (print): 0145-2126

ISSN (electronic): 1873-5835

Publisher: Pergamon


DOI: 10.1016/j.leukres.2007.03.027

PubMed id: 17543383


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