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Lookup NU author(s): Professor Anne Dickinson
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In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94+ NK cells. In the first 12 months after stem cell transplantation (SCT) CD94+ NK cells clearly dominate over CD3+/CD16-/56- T and CD3+/CD16+/56+ NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells. © 2007 Elsevier Ltd. All rights reserved.
Author(s): Gross C, Holler E, Stangl S, Dickinson AM, Pockley AG, Asea AA, Mallappa N, Multhoff G
Publication type: Article
Publication status: Published
Journal: Leukemia Research
Year: 2008
Volume: 32
Issue: 4
Pages: 527-534
ISSN (print): 0145-2126
ISSN (electronic): 1873-5835
Publisher: Pergamon
URL: http://dx.doi.org/10.1016/j.leukres.2007.03.027
DOI: 10.1016/j.leukres.2007.03.027
PubMed id: 17543383
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