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Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations

Lookup NU author(s): Professor John O'Brien, Dr Sean Colloby, Dr Sanjeet Pakrasi, Emeritus Professor Elaine Perry, Professor Ian McKeith, Professor David Williams


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Introduction: To investigate in vivo differences in the distribution of α4β2 subtypes of nAChR using the ligand 123I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in DLB and similarly aged controls. Methods: Thirty-one subjects (15 DLB and 16 controls) underwent 123I-5IA-85380 and perfusion (99mTc-exametazime) SPECT scanning. Patient scans were compared to scans of control subjects on a voxel-by-voxel basis using SPM2. Results: Compared to controls, significant reductions in relative 123I-5IA-85380 uptake were identified in frontal, striatal, temporal and cingulate regions in DLB. Elevation of scaled 123I-5IA-85380 uptake in occipital cortex was observed in DLB relative to controls, as well as being associated with DLB subjects with a recent history of visual hallucinations. Changes in 123I-5IA-85380 SPECT in DLB were different from perfusion. Conclusion: Reductions in normalised 123I-5IA-85380 uptake in DLB were distinct from their perfusion deficits. Significant increase in occipital lobe uptake was present in DLB, a change most pronounced in subjects with a recent history of visual hallucinations. The findings directly link cholinergic changes in occipital lobe to visual hallucinations in DLB. © 2008 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2008

Volume: 40

Issue: 3

Pages: 1056-1063

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Academic Press


DOI: 10.1016/j.neuroimage.2008.01.010

PubMed id: 18295510


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Funder referenceFunder name
G0400074Medical Research Council
G0502157Medical Research Council