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Lookup NU author(s): Dr Victoriya Doronina,
Dr Jeremy Brown
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Some RNA and protein sequences are capable of directing changes to the course of translation from that expected from the mRNA sequence, and this process is termed translational 'recoding'. 'CHYSEL' peptides are ε119-amino-acid sequences found in many viral genomes. When translated at internal portions of polypeptides, they yield co-translational separation of the nascent chain at their C-termini. We dissected the reaction promoted by CHYSEL sequences using yeast genetics and in vitro translation systems. Our results indicate that the reaction occurs within the peptidyltransferase centre of the ribosome where the nascent chain is hydrolytically released from tRNA despite the presence of further sense codons. © The Authors Journal compilation © 2008 Biochemical Society.
Author(s): Doronina VA, de Felipe P, Wu C, Sharma P, Sachs MS, Ryan MD, Brown JD
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 01/08/2008
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press Ltd.
PubMed id: 18631146
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