Toggle Main Menu Toggle Search

Open Access padlockePrints

Therapeutic T-cell manipulation in rheumatoid arthritis: Past, present and future

Lookup NU author(s): Professor John IsaacsORCiD



Accumulating evidence suggests that RA is a T-cell-mediated autoimmune disease. Early attempts at disease modulation using strategies such as CD4 mAbs were severely hampered by a lack of biomarkers of autoreactivity. Recently, however, co-stimulation blockade has emerged as an effective treatment for RA. Alongside a greatly improved mechanistic understanding of immune regulation, this has rekindled hopes for authentic and robust immune programming. The final pieces of the jigsaw are not yet in place for RA but, in other disciplines, emerging treatment paradigms such as non-mitogenic anti-CD3 mAbs, autoantigenic peptides and even cellular therapies are providing hope for a future in which immunopathology can be specifically and vigorously curtailed. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

Publication metadata

Author(s): Isaacs J

Publication type: Review

Publication status: Published

Journal: Rheumatology

Year: 2008

Volume: 47

Issue: 10

Pages: 1461-1468

ISSN (print): 1462-0324

ISSN (electronic): 1462-0332


DOI: 10.1093/rheumatology/ken163