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Lookup NU author(s): Dr Penelope Garrood,
Dr Michelle Eagle,
Emerita Professor Katherine Bushby,
Professor Volker StraubORCiD
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Myoglobinuria is a recognised complication of Duchenne muscular dystrophy (DMD), but has only once been reported in ambulant boys on corticosteroid therapy [Dubowitz V, Kinali M, Main M, Mercuri E, Muntoni F. Remission of clinical signs in early Duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy. Eur J Paediatr Neurol 2002;6(3):153-9.]. We present three prednisolone-treated boys with myoglobinuria and in two cases this was recurrent. All three showed improved motor performance in response to the introduction of corticosteroids. The greater activity of steroid-treated individuals may place their dystrophin-deficient muscles under greater mechanical stress, predisposing to further muscle fibre damage and consequent myoglobinuria. Families and physicians need to have an increased awareness of this possibility and of the appropriate management of myoglobinuria. © 2007 Elsevier B.V. All rights reserved.
Author(s): Garrood PVA, Eagle M, Jardine PE, Bushby KMD, Straub VW
Publication type: Article
Publication status: Published
Journal: Neuromuscular Disorders
Print publication date: 01/01/2008
ISSN (print): 0960-8966
ISSN (electronic): 1873-2364
PubMed id: 17719224
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