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Non-HLA genetics and predicting outcome in HSCT

Lookup NU author(s): Professor Anne Dickinson

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Abstract

Over the last 10 years, an increasing number of studies have demonstrated the role of non-human leukocyte antigen (HLA) genes in predicting outcome in haematopoietic stem cell transplantation (HSCT). These studies have included investigations into 'single nucleotide polymorphisms (SNPs)' or microsatellites of cytokines, cytokine receptor genes, or genes associating with innate immunity. These polymorphisms give rise to functional differences in the production of e.g. cytokines, or altered function of genes which are reflected in potential up- or down- regulating of the 'cytokine storm' of GvHD. This review summarises some of the studies and relates the results to their potential for improving HSCT outcome by predicting transplant-related mortality and GvHD. © 2008 The Author.

Publication metadata

Author(s): Dickinson AM

Publication type: Article

Publication status: Published

Journal: International Journal of Immunogenetics

Year: 2008

Volume: 35

Issue: 4-5

Pages: 375-380

Print publication date: 01/08/2008

ISSN (print): 1744-3121

ISSN (electronic): 1744-313X

Publisher: Blackwell Publishing

URL: http://dx.doi.org/10.1111/j.1744-313X.2008.00790.x

DOI: 10.1111/j.1744-313X.2008.00790.x

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