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Regulation of Trophoblast Invasion - A Workshop Report

Lookup NU author(s): Dr Gendie Lash


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Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms. © 2007 IFPA and Elsevier Ltd.

Publication metadata

Author(s): Knofler M, Simmons DG, Lash GE, Harris LK, Armant DR

Publication type: Article

Publication status: Published

Journal: Placenta

Year: 2008

Volume: 29

Issue: Supplement 1

Pages: 26-28

ISSN (print): 0143-4004

ISSN (electronic): 1532-3102

Publisher: Elsevier Ltd


DOI: 10.1016/j.placenta.2007.11.008

PubMed id: 18083227


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Funder referenceFunder name
Z99 HD999999Intramural NIH HHS