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Antidepressant-like activity of zinc: further behavioral and molecular evidence

Lookup NU author(s): Pawel Znojek


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Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression-chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17-39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF. © 2008 Springer-Verlag.

Publication metadata

Author(s): Sowa-Kucma M, Legutko B, Szewczyk B, Novak K, Znojek P, Poleszak E, Papp M, Pilc A, Nowak G

Publication type: Article

Publication status: Published

Journal: Journal of Neural Transmission

Year: 2008

Volume: 115

Issue: 12

Pages: 1621-1628

ISSN (print): 0300-9564

ISSN (electronic): 1435-1463

Publisher: Springer Wien


DOI: 10.1007/s00702-008-0115-7


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