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Birth weight of infants after maternal exposure to typical and atypical antipsychotics: Prospective comparison study

Lookup NU author(s): Dr James Newham, Professor Simon ThomasORCiD, Dr Karine Macritchie, Dr Patricia McElhatton, Professor Hamish McAllister-WilliamsORCiD


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Background: The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown. Aims: To determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy. Method: Prospective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to typical (n=45) and atypical (n=25) antipsychotics was compared with data for a reference group of infants (n=38). Results: Infants exposed to atypical antipsychotics had a significantly higher incidence of large for gestational age (LGA) than both comparison groups and a mean birth weight significantly heavier than those exposed to typical antipsychotics. In contrast those exposed to typical antipsychotics had a significantly lower mean birth weight and a higher incidence of small for gestational age infants than the reference group. Conclusions: In utero exposure to atypical antipsychotic drugs may increase infant birth weight and risk of LGA.

Publication metadata

Author(s): Newham JJ, Thomas SH, MacRitchie K, McElhatton PR, McAllister-Williams RH

Publication type: Article

Publication status: Published

Journal: British Journal of Psychiatry

Year: 2008

Volume: 192

Issue: 5

Pages: 333-337

ISSN (print): 0007-1250

ISSN (electronic): 1472-1465

Publisher: Royal College of Psychiatrists


DOI: 10.1192/bjp.bp.107.041541


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