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Lookup NU author(s): Alan Leake, Emeritus Professor Robert Perry, Professor Ian McKeith, Professor Jim Edwardson, Dr Christopher Morris
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The possibility of gene interactions in Alzheimer's disease (AD) has been suggested by the finding of an association of the AA genotype of the alpha-1 antichymotrypsin (AACT) gene and the apolipoprotein E (apoE) epsilon 4/4 genotype in AD. We tested this possibility by genotyping a large series of clinically and neuropathologically confirmed cases of AD and a series of cases with dementia with Lewy bodies (DLB) with a matched control group for the AACT locus and apoE. ApoE genotyping showed the established finding of an increased frequency of the apoE epsilon 4 allele in AD and in DLB. The AD and DLB groups differed between each other with a higher epsilon 2 allele frequency and a reduced incidence of the epsilon 4/4 genotype in DLB. Differences in the apoE frequencies may account for some of the differences between the two diseases. No association was found for the AACT A allele in AD or DLB in the groups as a whole or when stratified with respect to apoE, with the exception of a trend showing an increased incidence of the apoE epsilon 4/4 AACT AA genotype combination in AD patients (chi(2) = 3.18, p = 0.07), although in DLB this was not apparent (chi(2) = 0.0, p = 1.0). The AACT A allele is not a major risk factor for late-onset AD or DLB.
Author(s): McKeith IG; Edwardson JA; Perry RH; Leake A; Morris CM; Lamb H; Christie J; Singleton AB; Ince PG; Melton LM
Publication type: Article
Publication status: Published
Journal: Neurology
Year: 1998
Volume: 50
Issue: 2
Pages: 388-391
Print publication date: 01/02/1998
ISSN (print): 0028-3878
ISSN (electronic): 1526-632X
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1212/WNL.50.2.388
DOI: 10.1212/WNL.50.2.388
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