Toggle Main Menu Toggle Search

Open Access padlockePrints

Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies - Distinctions between diseases

Lookup NU author(s): Alan Leake, Emeritus Professor Robert Perry, Professor Ian McKeith, Professor Jim Edwardson, Dr Christopher Morris


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


The possibility of gene interactions in Alzheimer's disease (AD) has been suggested by the finding of an association of the AA genotype of the alpha-1 antichymotrypsin (AACT) gene and the apolipoprotein E (apoE) epsilon 4/4 genotype in AD. We tested this possibility by genotyping a large series of clinically and neuropathologically confirmed cases of AD and a series of cases with dementia with Lewy bodies (DLB) with a matched control group for the AACT locus and apoE. ApoE genotyping showed the established finding of an increased frequency of the apoE epsilon 4 allele in AD and in DLB. The AD and DLB groups differed between each other with a higher epsilon 2 allele frequency and a reduced incidence of the epsilon 4/4 genotype in DLB. Differences in the apoE frequencies may account for some of the differences between the two diseases. No association was found for the AACT A allele in AD or DLB in the groups as a whole or when stratified with respect to apoE, with the exception of a trend showing an increased incidence of the apoE epsilon 4/4 AACT AA genotype combination in AD patients (chi(2) = 3.18, p = 0.07), although in DLB this was not apparent (chi(2) = 0.0, p = 1.0). The AACT A allele is not a major risk factor for late-onset AD or DLB.

Publication metadata

Author(s): McKeith IG; Edwardson JA; Perry RH; Leake A; Morris CM; Lamb H; Christie J; Singleton AB; Ince PG; Melton LM

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 1998

Volume: 50

Issue: 2

Pages: 388-391

Print publication date: 01/02/1998

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1212/WNL.50.2.388


Altmetrics provided by Altmetric