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Lookup NU author(s): Dr Pamela Kearns,
Dr Andrew Hall
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In the past, the role of glutathione (GSH) in the production of drug resistance was assumed to be limited to electrophilic agents such as the bifunctional alkylating agents and cisplatin. Recently, however, evidence has emerged that links GSH homeostasis with regulation of the multidrug-resistance-related protein and the control of apoptotic cell death. These findings open up new avenues for the discovery of drugs that augment anticancer agents already in use or that have cytotoxic potential in their own right.
Author(s): Kearns PR, Hall AG
Publication type: Review
Publication status: Published
Journal: Drug Discovery Today
Print publication date: 01/03/1998
ISSN (print): 1359-6446
ISSN (electronic): 1878-5832