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Amphiphilic copolymer glycerol methacrylate networks: Synthesis and biointeractions

Lookup NU author(s): Dr Matthew GermanORCiD


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Block copolymer amphiphilic networks based on methacrylate repeat units were prepared, and the adhesion of cells and proteins were studied and compared to similar random copolymer hydrogels. Normal adult human fibroblasts were examined for their ability to attach and proliferate on networks using DNA analysis for cell number and electronmicroscopy for cell morphology. The random copolymers allowed adhesion of fibroblasts only in hydrogels that contained hydrophobic comonomers, such as butyl methacrylate or Lauryl methacrylate. The results show that increasing levels of DNA are only observed on materials that are composed of at least 75 wgt% butyl methacrylate (BMA).

Publication metadata

Author(s): German M; Rimmer S; Maughan J; MacNeil S; Yun S; Fullwood N

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Transactions: 7th World Biomaterials Congress

Year of Conference: 2004

Pages: 502

Publisher: Australian Society for Biomaterials

Notes: Conference Code: 64310 Export Date: 9 October 2007 Source: Scopus Language of Original Document: English Correspondence Address: Rimmer, S.; Ctr. Biomat. and Tissue Engineering; University of Sheffield Sheffield, United Kingdom

Library holdings: Search Newcastle University Library for this item

ISBN: 9781877040191