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High prevalence of neurovascular instability in neurodegenerative dementias

Lookup NU author(s): Dr Clive Ballard, Dr Fiona Shaw, Professor Ian McKeith, Professor Rose Anne Kenny


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Orthostatic hypotension and carotid sinus hypersensitivity were assessed in patients meeting clinical criteria for dementia with Lewy bodies (DLB; n = 30) and AD (n = 35). Cardioinhibitory carotid sinus hypersensitivity (CI) was the most common sign (AD patients, 28%; DLB patients, 41%). Preliminary data from a secondary analysis excluding patients with hypertension or EKG evidence of ischemia suggested that CI may be significantly more common in DLB. Larger studies are needed to evaluate the implications for treatment and to explore the underlying mechanisms.

Publication metadata

Author(s): McKeith I; Kenny R; Shaw F; Ballard C

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 1998

Volume: 51

Issue: 6

Pages: 1760-1762

Print publication date: 01/12/1998

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1212/WNL.51.6.1760


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