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Superoxide generation from constitutive nitric oxide synthase in astrocytes in vitro regulates extracellular nitric oxide availability

Lookup NU author(s): Emeritus Professor Calum McNeilORCiD


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Oxygen-derived free radicals play an important role in the physiology and pathophysiology of brain cell function. Because of their labile nature, however, it has been difficult to investigate their actions directly. This problem has been addressed, in primary rat brain cell cultures, in this study by utilization of two novel electrochemical sensors. It has been demonstrated that extracellular superoxide originates from the astrocytic subpopulation in a calcium/calmodulin dependent manner and responds to constitutive nitric oxide synthase inhibition. The results indicate a novel function for the astrocytic constitutive nitric oxide synthase in regulating extracellular superoxide release and, therefore, controlling neuronal nitric oxide availability. (C) 1998 Elsevier Science Inc.

Publication metadata

Author(s): Tolias CM, McNeil CJ, Kazlauskaite J, Hillhouse EW

Publication type: Article

Publication status: Published

Journal: Free Radical Biology and Medicine

Year: 1999

Volume: 26

Issue: 1-2

Pages: 99-106

Print publication date: 30/12/1998

ISSN (print): 0891-5849

ISSN (electronic): 1873-4596

Publisher: Elsevier Inc.


DOI: 10.1016/S0891-5849(98)00146-4


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