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Lookup NU author(s): Professor Jim Edwardson,
Emeritus Professor Robert Perry,
Professor Ian McKeith,
Dr Christopher Morris
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The frequency of various allele types of the class I Major Histocompatibility Complex (MHC) genes HLA-A and HLA-B were compared between pathologically confirmed groups of late and early-onset Alzheimer's disease (AD) and a control group, DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA-A and HLA-B genes were independently PCR amplified using specific primers. Individual allele types were identified using sequence-specific oligonucleotide probes. The results showed that the main frequency differences occurred between the late-onset AD and the control group however none of these reached statistical significance. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.
Author(s): McKeith I; Edwardson JA; Perry R; Morris C; Middleton D; Mawhinney H; Curran MD; Ince PG; Neill D
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Print publication date: 01/03/1999
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
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