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Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease

Lookup NU author(s): Professor Jim Edwardson, Emeritus Professor Robert Perry, Professor Ian McKeith, Dr Christopher Morris


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The frequency of various allele types of the class I Major Histocompatibility Complex (MHC) genes HLA-A and HLA-B were compared between pathologically confirmed groups of late and early-onset Alzheimer's disease (AD) and a control group, DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA-A and HLA-B genes were independently PCR amplified using specific primers. Individual allele types were identified using sequence-specific oligonucleotide probes. The results showed that the main frequency differences occurred between the late-onset AD and the control group however none of these reached statistical significance. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

Publication metadata

Author(s): McKeith I; Edwardson JA; Perry R; Morris C; Middleton D; Mawhinney H; Curran MD; Ince PG; Neill D

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 1999

Volume: 262

Issue: 2

Pages: 140-142

Print publication date: 01/03/1999

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier


DOI: 10.1016/S0304-3940(99)00045-2


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