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The effects of testosterone on osteoporosis in men

Lookup NU author(s): Emeritus Professor Roger Francis

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Abstract

Although the pathogenesis of osteoporosis in men is multi-factorial, testosterone is known to play an important role in the maintenance of the male skeleton. This role, however, appears complicated as it may be mediated in part by aromatization to oestradiol. Testosterone replacement therapy improves bone density in men with hypogonadal osteoporosis, particularly if the epiphyses are still open. There is no well-established treatment for idiopathic osteoporosis in men, but testosterone supplementation may prove to be useful. Further studies are required to confirm the safety and efficacy of this treatment in eugonadal men with osteoporosis.

Publication metadata

Author(s): Francis RM

Publication type: Review

Publication status: Published

Journal: Clinical Endocrinology

Year: 1999

Volume: 50

Issue: 4

Pages: 411-414

ISSN (print): 0300-0664

ISSN (electronic): 1365-2265

URL: http://dx.doi.org/10.1046/j.1365-2265.1999.00730.x

DOI: 10.1046/j.1365-2265.1999.00730.x

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