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Lookup NU author(s): Dr Julian Thomas, Dr Anne Dale, Dr David Campbell
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The C-13-urea breath test is a noninvasive tool for the diagnosis of gastric Helicobacter pylori infection. However, it has not been validated in young children from the developing world, where infection is very common. C-13 urea breath tests were performed on 1532 occasions on 247 Gambian infants and children aged from 3 to 48 mo. The means and variances of the separate sub-populations of C-13 enrichment results contained within the overall dataset were estimated by a Genstat procedure using the EM algorithm, thereby identifying a cut-off value to discriminate positive from negative results. To illustrate the appropriateness of this calculated cut-off value, C-13 urea breath tests were performed upon a small group of 14 patients aged 6 to 28 mo undergoing diagnostic upper endoscopy. Fixed gastric antral biopsies were examined to identify H. pylori. Two subpopulations were identified within the large dataset. A cut-off value of 5.47 delta parts per thousand relative to Pee Dee Belemnite Limestone above baseline at 30 min identified 95% of the normally distributed negative sub-population and 99.4% of the log normal distributed positive sub-population. Comparison with endoscopic data confirmed that this cut-off Value was appropriate for this population, as 7/7 children without H. pylori on their gastric biopsies had negative urea breath tests, and 6/7 children with gastric H. pylori colonization had positive urea breath tests. These findings confirm the value of the urea breath test as a diagnostic tool in young children from developing countries. They also offer a way to calculate the most appropriate cut-off Value for use in different populations and the Likelihood that it will correctly assign any value into the appropriate sub-population, without the need for endoscopy.
Author(s): Dale A; Campbell DI; Thomas JE; Harding M; Coward WA; Cole TJ; Sullivan PB; Warren BF; Weaver LT
Publication type: Article
Publication status: Published
Journal: Pediatric Research
Year: 1999
Volume: 46
Issue: 2
Pages: 147-151
Print publication date: 01/08/1999
ISSN (print): 0031-3998
ISSN (electronic): 1530-0447
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1203/00006450-199908000-00003
DOI: 10.1203/00006450-199908000-00003
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