Browse by author
Lookup NU author(s): Dr John Perry,
Professor Kate Gould
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Glycopeptides have been recommended as therapy for endocarditis. MICs and MBCs of vancomycin and teicoplanin were compared for 100 isolates from patients with proven bacterial endocarditis. MICs were generally lower for teicoplanin and tolerance to both agents was common. Almost all isolates of enterococci were tolerant to both glycopeptides. Among the streptococci, 78% were tolerant to teicoplanin and 57% to vancomycin. Similar findings were demonstrated for staphylococci. Although isolates appear sensitive to glycopeptides, bactericidal activity cannot always be predicted. If a glycopeptide is indicated for treatment of endocarditis, combination therapy with a suitable aminoglycoside should be considered unless MBC testing can be performed.
Author(s): Jones AL; Gould FK; Perry JD
Publication type: Article
Publication status: Published
Journal: Journal of Antimicrobial Chemotherapy
Print publication date: 01/07/1999
ISSN (print): 0305-7453
ISSN (electronic): 1460-2091
Publisher: Oxford University Press
Altmetrics provided by Altmetric