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Glycopeptide tolerance in bacteria causing endocarditis

Lookup NU author(s): Dr John Perry, Amanda Jones, Professor Kate Gould


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Glycopeptides have been recommended as therapy for endocarditis. MICs and MBCs of vancomycin and teicoplanin were compared for 100 isolates from patients with proven bacterial endocarditis. MICs were generally lower for teicoplanin and tolerance to both agents was common. Almost all isolates of enterococci were tolerant to both glycopeptides. Among the streptococci, 78% were tolerant to teicoplanin and 57% to vancomycin. Similar findings were demonstrated for staphylococci. Although isolates appear sensitive to glycopeptides, bactericidal activity cannot always be predicted. If a glycopeptide is indicated for treatment of endocarditis, combination therapy with a suitable aminoglycoside should be considered unless MBC testing can be performed.

Publication metadata

Author(s): Jones AL; Gould FK; Perry JD

Publication type: Article

Publication status: Published

Journal: Journal of Antimicrobial Chemotherapy

Year: 1999

Volume: 44

Issue: 1

Pages: 121-124

Print publication date: 01/07/1999

ISSN (print): 0305-7453

ISSN (electronic): 1460-2091

Publisher: Oxford University Press


DOI: 10.1093/jac/44.1.121


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