Toggle Main Menu Toggle Search

Open Access padlockePrints

Dose-related nephrotoxicity of carboplatin in children

Lookup NU author(s): Professor Roderick Skinner, Professor Andrew Pearson, Emeritus Professor Alan Craft


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


This study investigated changes and the time course of these changes in renal function in children following treatment with carboplatin, and identified risk factors for nephrotoxicity. Glomerular and proximal renal tubular function were investigated before and up to 2 years after treatment in 23 children who received carboplatin. The main findings were reduced glomerular filtration rate (GFR), and increased renal tubular loss of magnesium, manifested by a low serum magnesium (S Mg). The mean fall in GFR was 22 ml min(-1) 1.73 m(-2) (P = 0.012), and in S Mg it was 0.17 mmol l(-1) (P = 0.0077). No patient had a clinically important reduction in GFR, and only one patient had symptomatic hypomagnesaemia. GFR and S Mg did not change over time after completion of treatment. Cumulative dose (CD) of carboplatin was inversely related to mean S Mg at the end of treatment (P = 0.031), and directly related to the fall in S Mg (P < 0.001). Calculated cumulative area under the plasma concentration versus time curve (AUC) of carboplatin was inversely related to S Mg after treatment (P = 0.004). Dose intensity (DI) of carboplatin was not shown to be related to S Mg following treatment. CD, AUC and DI of carboplatin were not related to GFR, nor change in GFR, after treatment. High CDs of carboplatin may be associated with evidence of renal damage qualitatively similar to but less severe than that caused by cisplatin. GFR and SMg should be carefully monitored when high CDs of carboplatin are used, or if carboplatin is combined with other nephrotoxic chemotherapy. (C) 1999 Cancer Research Campaign.

Publication metadata

Author(s): English, M. W., Skinner, R., Pearson, A. D. J., Price, L., Wyllie, R., Craft, A. W.

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1999

Volume: 81

Issue: 2

Pages: 336-341

Print publication date: 01/09/1999

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827


DOI: 10.1038/sj.bjc.6690697

PubMed id: 10496362


Altmetrics provided by Altmetric