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Lookup NU author(s): Colin Hilton, Dr Stephen Furniss
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Heart failure is the leading cause of death in patients after surgery for ventricular tachycardia. This study examines the effects of antiarrhythmic surgery on 4 parameters of left ventricular (LV) function. Global ejection fraction, segmental wall motion score, homogeneity of contraction, and diastolic Function were measured in 32 patients by technetium-99m radionuclide ventriculography. Ejection fraction was measured from the left anterior oblique image. Wall motion score was assessed semiquantitatively for 11 LV segments from 3 projections. Homogeneity of contraction was expressed as the SD of the LV phase analysis curve during systole from the left anterior oblique image. Diastolic function was expressed in terms of peak and mean first time derivative of the action potential (dV/dt) of the LV function curve. Subgroup analyses were performed to distinguish the effects of aneurysmectomy, coronary artery bypass grafting, and changes in angiotensin converting enzyme inhibitor therapy. Mean systolic function improved after surgery (ejection fraction 22% vs 32%, p <0001; wall motion score: 20 vs 13, p <0.0001; phase analysis 18 vs 12, p <0.03), Mean diastolic function also improved (peak dV/dt 0.83 +/- 0.32 vs 1.49 +/- 0.35, p = 0.006; mean dV/dt 0.41 +/- 0.15 vs 0.76 +/- 0.27, p = 0.006), Improvements were not confined to those who had aneurysmectomy or coronary bypass grafting and were not explained by changes in vasodilator therapy. Thus, antiarrhythmic surgery does not inherently damage LV function. Significant improvements were observed in most patients. Failure to improve indicated a poor longer term prognosis. (C)2000 by Excerpta Medico, Inc.
Author(s): Bourke JP, Hawkins T, Hilton CJ, Keavey PM, Furniss SS, Campbell RWF
Publication type: Article
Publication status: Published
Journal: American Journal of Cardiology
Year: 2000
Volume: 85
Issue: 6
Pages: 703-709
ISSN (print): 0002-9149
ISSN (electronic): 1879-1913
Publisher: Excerpta Medica Inc.
URL: http://dx.doi.org/10.1016/S0002-9149(99)00844-9
DOI: 10.1016/S0002-9149(99)00844-9
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