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Lookup NU author(s): Dr Clive Ballard, Professor Ian McKeith, Professor John O'Brien, Professor Raj KalariaORCiD, Dr Evelyn Jaros, Emeritus Professor Robert Perry
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The neuropathological substrates of dementia and depression were evaluated in 30 patients with cerebrovascular disease and significant cognitive impairment (VaD), with a particular focus on patients with small infarct volumes (<15 ml). VaD patients with small infarct volumes had a similar degree of cognitive impairment to those with larger infarct volumes (>15 ml) but were significantly more likely to be depressed and to have areas of microinfarction. A review of individual cases with small infarct volumes suggested that the combination of microinfarction, diffuse white matter disease and perivascular changes, or the overlap of neurodegenerative pathologies and microvascular changes were particularly important. Microinfarction was also significantly associated with major depression. Copyright (C) 2000 S. Karger AG, Basel.
Author(s): McKeith I; Kalaria R; Perry R; O'Brien J; Ballard C; Jaros E; Ince P
Publication type: Article
Publication status: Published
Journal: Dementia and Geriatric Cognitive Disorders
Year: 2000
Volume: 11
Issue: 2
Pages: 59-65
ISSN (print): 0077-8923
ISSN (electronic): 1749-6632
Publisher: Wiley-Blackwell Publishing Ltd.
URL: .htp://x.doi.org/10.1159/000017215
DOI: 10.1159/000017215
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