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Molecular gerontology - Bridging the simple and the complex

Lookup NU author(s): Emeritus Professor Thomas Kirkwood


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It is clear, both empirically and theoretically, that the mechanisms of aging are multiple and complex. Nevertheless, single gene mutations and simple interventions such as calorie restriction have broad effects on the senescent phenotype. The major challenge is to unite highly reductionist analysis of molecular components with integrative model systems that can "put it all together," Two themes are developed. In the first, biochemical models are described that show how the network concept of cellular aging can be used to integrate multiple biochemical mechanisms that contribute to cellular instability. In the second theme, the role of intrinsic developmental chance is examined as a major factor contributing, in addition to genes and environment, to the divergence of the senescent phenotype. The implications of these themes for research strategies in molecular gerontology are discussed.

Publication metadata

Author(s): Kirkwood TBL

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: EMBO Workshop on Molecular and Cellular Gerontology - 1999

Year of Conference: 1999

Pages: 14-20

ISSN: 0261-4189

Publisher: Nature Publishing Group


DOI: 10.1093/emboj/19.9.1929

Library holdings: Search Newcastle University Library for this item

ISBN: 14602075