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Lookup NU author(s): Emeritus Professor Thomas Kirkwood
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It is clear, both empirically and theoretically, that the mechanisms of aging are multiple and complex. Nevertheless, single gene mutations and simple interventions such as calorie restriction have broad effects on the senescent phenotype. The major challenge is to unite highly reductionist analysis of molecular components with integrative model systems that can "put it all together," Two themes are developed. In the first, biochemical models are described that show how the network concept of cellular aging can be used to integrate multiple biochemical mechanisms that contribute to cellular instability. In the second theme, the role of intrinsic developmental chance is examined as a major factor contributing, in addition to genes and environment, to the divergence of the senescent phenotype. The implications of these themes for research strategies in molecular gerontology are discussed.
Author(s): Kirkwood TBL
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: EMBO Workshop on Molecular and Cellular Gerontology - 1999
Year of Conference: 1999
Pages: 14-20
ISSN: 0261-4189
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1093/emboj/19.9.1929
DOI: 10.1093/emboj/19.9.1929
Library holdings: Search Newcastle University Library for this item
ISBN: 14602075
